Burger's Medicinal Chemistry and Drug Discovery, Drug by Donald J. Abraham

By Donald J. Abraham

This can be quantity 2: Drug Discovery and Drug Development, of Burger's Medicinal Chemistry and Drug Discovery, sixth variation. This new quantity comprises serious new chapters on Combinational Chemistry and a number of Parallel Synthesis, excessive Throughput Pharmacology, and Retrometabolism-Based Drug layout and concentrating on.

To buy the whole 6 quantity set, please seek advice from ISBN 0-471-37032-0.

Show description

Read or Download Burger's Medicinal Chemistry and Drug Discovery, Drug Discovery and Drug Development (Volume 2) PDF

Similar pharmacy books

Pharmaceutical Packaging Handbook

This identify provides an outline of the position packaging performs within the improvement and supply of pharmaceuticals-introducing the reader to drug dosage kinds, vaccines, biologically produced items, and scientific meals, and discussing how packaging is designed and built-in into the product improvement cycle.

Pocket Prescriber

A brand new annual variation of this well known pocket drug advisor. it really is totally up to date with the inclusion of latest medications and with previous medicinal drugs being got rid of. It presents the main crucial medical pharmacology info that busy clinicians desire by way of targeting the main commone 500 pharmaceuticals.

Wilson and Gisvold's Textbook of Organic Medicinal and Pharmaceutical Chemistry, 12th Edition

For over part a century, Wilson and Gisvold's Textbook of natural Medicinal and Pharmaceutical Chemistry has served the self-discipline of medicinal chemistry for either graduate and undergraduate pharmacy and chemistry scholars in addition to working towards pharmacists. totally up-to-date for the 12th variation, the e-book starts off with the basic rules of chemistry, biochemistry, and biology that underlie the self-discipline of medicinal chemistry.

The Anticipation of Converging Industries: A Concept Applied to Nutraceuticals and Functional Foods

The blurring of obstacles among hitherto special medical disciplines, applied sciences or markets is a typical and strong phenomenon. topics of this convergence frequently switch client behaviours, favouring items and structures with a number of services. The Anticipation of Converging Industries offers an in depth concentrate on the triggers, drivers and outcomes of convergence to create a extra concise definition of convergence.

Additional info for Burger's Medicinal Chemistry and Drug Discovery, Drug Discovery and Drug Development (Volume 2)

Example text

97 suggests that hydrophobicity is more important in this area. 2 Interactions at the Cellular Level QSAR analysis of studies at the cellular level allows us to get a handle on the physicochemical parameters critical to pharmacokinetics processes, mostly transport. Cell culture systems offer an ideal way to determine the optimum hydrophobicity of a system that is more complex than an isolated receptor. Extensive QSAR have been developed on the toxicity of 3-X-triazines to many mammalian and bacterial cell lines (202, 209).

C . Hansch and A. Leo, Substituent Constants for Correlation Analysis in Chemistry and Biology, John Wiley & Sons, New York, 1979. References 2. D. J. Livingstone, J. Chem. Znf. Comput. , 40,195 (2000). 3. C. Hansch, A. Kurup, R. Garg, and H. Gao, Chem. , 101,619 (2001). 4. H. Kubinyi in M. , Burger's Medicinal Chemistry and Drug Discovery, Volume 1: Principles and Practice, John Wiley & Sons, New York, 1995, p. 497. 5. A. Crum-Brown and T. R. Fraser, Trans. R. Soc. Edinburgh, 25, 151 (1868). 6.

Nevertheless, sterics are of overwhelming importance in ligand-receptor interactions as well as in transport phenomena in cellular systems. The first steric parameter to be quantified and used in QSAR studies was Taft's Es constant (157). Es is defined as where k , and k , represent the rates of acid hydrolysis of esters, XCH,COOR and CH,COOR, History of Quantitative Structure-Activity Relationships respectively. 306 is a constant derived from molecular orbital calculations (158). Unfortunately, the limited availability of Es and E s C values for a great number of substituents precludes their usage in QSAR studies.

Download PDF sample

Rated 4.73 of 5 – based on 44 votes