Autistic spectrum disorders in children by Vidya Bhushan Gupta

By Vidya Bhushan Gupta

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Am J Med Genet 1990; 36(1):85–88. Philippe A, Martinez M, Guilloud-Bataille M, Gillberg C, Rastam M, Sponheim E, et al. Genome-wide scan for autism susceptibility genes. Paris Autism Research International Sibpair Study. Hum Mol Genet 1999; 8(5):805– 812. A genomewide screen for autism: strong evidence for linkage to chromosomes 2q, 7q, and 16p. International Molecular Genetic Study of Autism Consortium. Am J Hum Genet 2001; 69(3):570– 581. Copyright © 2004 Marcel Dekker, Inc. 40 61. 62. 63. 64.

Absence or abnormality of language; 3. resistance to change or attachment to objects; Copyright © 2004 Marcel Dekker, Inc. 26 Karapurkar et al. 4. 5. absence of schizophrenic features; and onset before 30 months of age. DSM-III also included childhood-onset PDD (onset after 30 months of age and before 12 years of age) and described a subthreshold condition, atypical PDD. In 1987 the DSM-III criteria were revised and led to the broadening of the concept of PDD. The concept of autism as a spectrum of disorders was first described by Wing and Gould in 1979 (19) and was likely influenced by the work of Hans Asperger, whose writings describing related behaviors did not become well known in the English literature until the 1980s (20).

2). 1/10,000 for the 13 studies that were conducted between Figure 2 Trend in prevalence of autism by time period studied. Copyright © 2004 Marcel Dekker, Inc. Epidemiology of Autism 29 1990 and 1999 (8,38 – 49). The mean rates that were established for each decade that the studies were conducted show a similar pattern as the trend seen with the weighted prevalence estimates; however, larger differences are seen in the mean rates from one decade to the next. 8 in the 1990s (Fig. 2). These data, showing the rise in prevalence by time period of study, may be reflective of the changing diagnostic criteria used over these four decades, but may also be reflective of other factors such as increased awareness and diagnosis of the disorder.

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