Alkaline Phosphatase by Robert B. McComb

By Robert B. McComb

There may be doubtless that alkaline phosphatase is likely one of the such a lot commonly in­ vestigated of all enzymes. This has resulted from the ubiquity of its distribution, and from the convenience and sensitivity with which its task could be measured. regrettably, those wide-ranging yet usually superficial experimental reports were up via in depth and systematic investigations in just a couple of constrained parts of the biochemistry and chemical pathology of alkaline phosphatase. the end result has been the buildup of a systematic literature of intimidating proportions, and the inevitable rediscovery of already­ identified proof concerning the enzyme. Scientists are taught early of their careers that, within the phrases of Sir John Herschel, "Hasty generalization is the bane of technological know-how. " however, moments arrive in all spheres of medical task whilst generalization turns into crucial, to codify and to choose between the mass of knowledge already gathered, and to supply beginning issues for brand spanking new advancements and new traces of research. this can be very true in a box equivalent to alkaline phosphatase study, within which very actual risks exist that the seeds of basic realizing should be misplaced amidst an unexamined harvest of empirical observations. The background of the research of alkaline phosphatase presents numerous cases whilst useful generalizations have emerged. sometimes, the conclusions drawn at the foundation of accessible proof have been unsuitable; extra usually, they've got stood the try of additional experimentation, and continuously, they've got supplied new insights into the character and correct­ ties of this enzyme.

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213. aark, S. , The localization of alkaline phosphatase in tissues of mice using the electron microscope, Am. J. , 109, 57,1961. 214. , Electron microscopic localization of phosphatase activity in the brush border of the rat kidney, J. Histochem. , 11, 447, 1963. 215. Takano. , Immunohistochemical study on alkaline phosphatase in bovine intestine: A preliminary report, Okajimas Folia Anat. , 48, 91, 1971. 216. , Purification and immunohistochemical study of alkaline phosphatase in bovine kidney.

Simpson, R. , and Vallee, B. L, Two differentiable classes of metal atoms in alkaline phosphatase of Escherichia coli, Biochernistry, 7,4343, 1968. 102. , and Schlesinger, M. , The effect of amino acid analogues on alkaline phosphatase formation in Escherichia coli K-12: Substitution of 2-methylhistidine for histidine, 1. Bioi. , 244, 3803, 1969. 103. , Schlesinger, M. , The effect of amino acid analogues on alkaline phosphatase formation in Escherichia coli K-12. IV. Substitution of canavanine for arginine, 1.

156. Jencks, W. , Catalysis in Chemistry and Enzymology, p. 43, McGraw-Hill, New York, 1969. 157. Dox, A. , The phosphatase assimilation of Aspergillus niger, J. Bioi. , 10, 77, 1911. 158. Dox, A. , Phytase in lower fungi, I. Bioi. , 10, 183, 1911. 159. , Uber die Spaltung der mono-phenyl-phosphorsiiuren und monoiithyl-phosphorsiiuren Salze durch pflanzliche und tierische Phosphatase, Biochem. , 173, 348, 1926. 160. Pett, L. , and Wynne, A. , Studies on bacterial phosphatases: The phosphatases of Aerobacter aerogenes, Alcaligenes faecalis and Bacillus subtilis, Biochem.

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