By P N Kourounakis
The dept of Pharmaceutical-Medicinal Chemistry, university of Pharmacy, Aristotelian collage of Thessaloniki, organizes, another yr, a graduate seminar in complicated medicinal chemistry, with foreign participation, in Thessaloniki. the aim of this seminar is to assist younger and impressive pharmaceutical scientists during this box by means of updating their wisdom and informing them concerning the new tendencies in our technological know-how, in the course of the shows of popular invited audio system. it's also aimed to create a discussion board for trade of principles in medicinal chemistry, in a distinct casual surroundings, bringinginternationally well-known medicinal chemists toward their Greek colleagues. a few of the invited audio system during this sequence of seminars are: A.H.Beckett, A.Benakis, N.Bodor, D.D.Breimer, J.Caldwell, R.Ganellin, J.Gorrod, R.Franke, H.Kappus, P.Krogsgaard-Larsen, A.Makriyiannis, J.Seydel, H.Sies, J.Tollenaere and W.Wiegrebe.
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Additional info for Advanced Drug Design and Development: A Medicinal Chemistry Approach
APPA actually is the first example of a partial agonist at AMPA receptors . AMPA RECEPTOR ANTAGONISTS The specificity of (S)-AMPA as an agonist at AMPA receptors is assumed to be associated with the rigid and planar structure of the acidic 3-isoxazolol unit of this compound (Fig. 14) as established by X-ray crystallography [66–69]. This heterocyclic nucleus is a bioisostere of the terminal carboxyl group of Glu, and the structural characteristics of AMPA are only to a limited extent shared by the structurally related heterocyclic amino acid QUIS .
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